OBJECTIVES The aim of this study was to design and evaluate a chitosan-based film that has properties required for successful wound dressing, and can control drug penetration and maintenance time in the location. METHODS Several formulations of a film containing chitosan (3%) and different concentrations of Eudragit RL (0.5%, 1%, and 1.5%) were prepared using the casting/solvent evaporating t...

objective(s): ketotifen fumarate (kf) is a selective and noncompetitive histamine antagonist (h1-receptor) that is used topically in the treatment of allergic conditions of rhinitis and conjunctivitis. the aim of this study was to formulate and improve an ophthalmic delivery system of kf.ocular nanoparticles were prepared with the objective of reducing the frequency of administration and obtain...

Effervescent multiple-unit floating drug delivery systems (muFDDSs) consisting of drug (lorsartan)- and effervescent (sodium bicarbonate)-containing pellets were characterized in this study. The mechanical properties (stress and strain at rupture, Young's modulus, and toughness) of these plasticized polymeric films of acrylic (Eudragit RS, RL, and NE) and cellulosic materials (ethyl cellulose (...

The present study was designed to investigate the effect of different types of coating polymers such as Eudragit RL 30D, Eudragit RS 30D, Eudragit NE 30D, Surelease, and Kollicoat SR 30D on physical properties and release pattern of salbutamol sulphate (SS) pellets which were prepared by Extrusion-Spheronization technology. All the polymers used in coating solution were in aqueous dispersion fo...

OBJECTIVES The aim of this study was to investigate the possibility of production of ibuprofen pellets with high amount of rate retarding polymer by aid of PEG400 as plasticizer. MATERIALS AND METHODS Polyethylene glycol (PEG400) in concentrations of 1, 3 or 5% w/w with respect to Eudragit RL was used in production of pellets containing 60% ibuprofen and 40% excipient (2% polyvinylpyrrolidone...

The objective of the present work was to develop a suitable transdermal drug delivery system for nitrendipine. Polymeric films of nitrendipine were prepared by the film casting technique (glass ring) on mercury substrate. They were evaluated for physicochemical parameters, in vitro release and ex vivo permeation (heat separated human epidermis). Release of the drug from the films followed anoma...

A sustained release dosage form of Metformin HCl in the form of microspheres was prepared by the solvent evaporation method. Solvent evaporation method was attempted in both aqueous as well as oily manufacturing vehicles. Different polymers such as Ethyl Cellulose, Eudragit RS PO, Eudragit RL PO, Eudragit S 100, Eudragit RL 100 and different combinations of these polymers were tried and the res...

ISSN:0975-1459 Sustained release microcapsules of acetazolamide, a short half life carbonic anhydrase inhibitor, was developed to reduce the frequency of drug administration, ease of dose adjustment and improve patient compliance. In this study, sustained release microcapsules of acetazolamide was prepared by solvent evaporation techniques using Eudragit RL/RS as polymer and particle size, enca...

Objective. The purpose of the recent study was to prepare and estimate sustained release of Ethylcellulose (300 cps) and Eudragit (RS 100 and RL 100) microparticles containing Propranolol hydrochloride used as a treatment of cardiovascular system, especially hypertension. Method. Propranolol hydrochloride was microencapsulated with different polymers (Ethylcellulose, Eudragit RS, and Eudragit R...

objective(s) the aim of this study was to investigate the possibility of production of ibuprofen pellets with high amount of rate retarding polymer by aid of peg400 as plasticizer. materials and methods polyethylene glycol (peg400) in concentrations of 1, 3 or 5% w/w with respect to eudragit rl was used in production of pellets containing 60% ibuprofen and 40% excipient (2% polyvinylpyrrolidone...